Abstract
A series of sebacoyl N,N-bis(substituted-alkyl-2-thioureido)alkyl carboxylic acid or ester derivatives 3-12 bearing an amino acid ester residue were prepared by a one-pot sequential reaction of sebacoyl chloride 1 with NH4SCN and amino acid or their ester hydrochlorides. Analogously, the sebacoyl-phthalimido derivatives 16 and 17 were prepared from treatment of 1 with phthalimide precursors. Treatment of 5 and 7 with Br2 in acetone furnished the iminothiazole analogues 18 and 19, respectively. Compounds 5, 6, 8-11 and 16 have been selected for their inhibitory activity screening against HIV-1 and HIV-2 in MT-4 cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
