Abstract
AbstractA polyglycerol dendrimer (PGD), which is known as a biocompatible compound, was demonstrated as a host molecule for amino acids. PGD of generation 3 (PGD‐G3) was found to interact with basic α‐amino acids such as l‐arginine (Arg) and l‐lysine (Lys) in water. The results of isothermal titration calorimetry, 1H NMR, and 1H‐1H NOESY NMR measurements revealed that two basic groups in α‐amino acids were essential for encapsulation by PGD‐G3. An increase in the pKa value of the amino acid side chains (Arg>Lys>His>Glu) increased the binding constant, thus suggesting that the basicity of α‐amino acids is an important factor to interact with ether oxygen of PGD‐G3. The results demonstrate the utility of PGD‐G3 toward incorporation of α‐amino acids, peptides, and basic proteins in water.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
