Abstract
The amino acid composition of serum high density lipoprotein (HDL) from two patients with LCAT deficiency has been investigated. HDL from the patients was composed of two fractions, one of high molecular weight (peak 1) and one of relatively low molecular weight (peak II). The amino acid composition of peak I was close lo that of normal HDL except for lower levels of serine and glutamic acid and a higher level of isoleucine. In peak II increased amounts of histicline and arginine and decreased amounts of threonine, serine, proline, methionine, isoleucine, tyrosine, phenylalanine, and cysteine were found.
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