Amino Acid Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications Through a Novel Efficient Preparation Method

Abstract

An efficient and applicable method to synthesize the amino acid coated magnetite nanoparticles (MNPs) was developed. A quality control of the amino acid coated MNPs were performed by various techniques of X-ray diffraction, FT-IR, FE-SEM, TEM, DLS, VSM and DSC-TGA techniques. Structural analyses by XRD and IR confirmed that the electro-synthesized samples have composition of pure magnetite (Fe3O4) phase with crystal size of about 8 nm. Morphological characterization by FE-SEM and TEM showed that all the prepared samples have uniform spherical particles with size about 10 nm. The amine coat on the surface of MNPs was confirmed by FT-IR, DSC-TGA and DLS analyses. The superparamagnetic properties of the prepared NPs were verified by VSM data, where the lysine coated Fe3O4 NPs exhibited suitable magnetization value (Ms = 55.9 emu g−1), negligible coercivity (Ce = 0.9 Oe) and magnetic remanence (Mr = 0.55 emu g−1) values. The results confirmed that the prepared amino acid coated MNPs have proper size, dispersion and magnetic properties for biomedical applications.