Abstract
ABSTRACT 5-Hydroxytryptamine (5-HT) or dopamine (DA) in large doses elicited increased levels of blood 131I and plasma protein-bound 131I in thyroxine-blocked or hypophysectomized but not in normal NMRI mice. The responses were similar to those following small doses of thyrotrophin. l-5-Hydroxytryptophan or l-dihydroxyphenylalanine gave similar responses. This effect was abolished by pretreatment with an aromatic amino acid decarboxylase inhibitor, and the effect of the amines was augmented by pretreatment with a monoamine oxidase inhibitor. It was concluded that, in the NMRI mouse, large doses of 5-HT or DA stimulate thyroid hormone release, and that this thyroid-stimulating effect is elicited directly within the thyroid gland.
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