Amine-Grafted Mesoporous Carbons as Benzocaine-Delivery Platforms.

Joanna Goscianska,Dominika Ludowicz,Anita Kubiak,Anna Stasiłowicz,Judyta Cielecka-Piontek,Aleksander Ejsmont

doi:10.3390/ma14092188

Joanna Goscianska, Dominika Ludowicz + Show 4 more

Open Access

https://doi.org/10.3390/ma14092188

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Abstract

Smart porous carriers with defined structure and physicochemical properties are required for releasing the therapeutic drug with precise control of delivery time and location in the body. Due to their non-toxicity, ordered structure, and chemical and thermal stability, mesoporous carbons can be considered modern carriers for active pharmaceutical ingredients whose effectiveness needs frequent dosing algorithms. Here, the novel benzocaine delivery systems based on ordered mesoporous carbons of the cubic structure were obtained with the use of a hard template method and functionalization with amine groups at 40 °C for 8 h. It has been shown that amine grafting strongly modifies the surface chemistry and textural parameters of carbons. All samples indicated good sorption ability towards benzocaine, with evident improvement following the functionalization with the amine groups. The sorption capacity and drug release kinetics were strongly affected by the porosity of carbon carriers and the surface functional groups. The smallest amount of benzocaine (~12%) was released from pristine mesoporous carbon, which could be correlated with strong API–carrier interactions. Faster and more efficient release of the drug was observed in the case of triethylenetetramine modified carbon (~62%). All benzocaine delivery platforms based on amine-grafted mesoporous carbons revealed high permeability through the artificial membrane.

Highlights

At a time when versatile materials are sought to perform specific functions via appropriate modulations, ordered mesoporous carbons (OMCs) seem to be an endless source of possibilities [1,2]
It can be stated that pristine mesoporous carbon was successfully synthesized with the use of a KIT-6 silica template
It was shown that carbon carriers possessing the number of nitrogen-containing functional groups, stimulating the intensification of host

Summary

Introduction

At a time when versatile materials are sought to perform specific functions via appropriate modulations, ordered mesoporous carbons (OMCs) seem to be an endless source of possibilities [1,2]. Their highly tunable properties, such as porosity in the range of. OMCs and their adsorption capabilities have been applied in various fields, such as hydrogen [3] and energy [4] storage, catalysis [5,6], gas capture [7,8], water treatment [9,10], and drug delivery [11,12] Whilst the latter application of OMCs as carriers for active pharmaceutical ingredients (APIs) is newly emerging, they are more often considered due to their confirmed biocompatibility [13,14,15]. The use of carbons as drug carriers is intended to improve the delivery of APIs characterized by poor solubility, chemical lability, or/and instability, to the target place in the body [19,20]

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