Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH

Kazunori Kataoka,Teruo Okano,Kazuo Matsuyama,Yasuhisa Sakurai,Yoshiyuki Koyama,Daijiro Shiino

doi:10.1007/978-4-431-65883-2_120

Amine Effect on Controlled Release of Insulin from Phenylboronic Acid Gel in Physiological pH

Kazunori Kataoka, Teruo Okano + Show 4 more

https://doi.org/10.1007/978-4-431-65883-2_120

Copy DOI

Publication Date: Jan 1, 1996

Affiliation: Tokyo University of Science, Otsuma Women's University, NOF Corporation (Japan)

#Phenylboronic Acid #Phenylboronic Acid Group + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

An insulin delivery system comprising phenylboronic acid (PBA) hydrogel was investigated for efficacy at physiological pH by an addition of amino moiety. Release of gluconated insulin from hydrogel beads having PBA group responded to glucose concentration was strongly affected by the incorporation of amine group in the beads under physiological pH. Released G-Ins indicates 17600 mIU/cm3·day, that value is practical for in vivo application. These results indicate the feasibility of insulin delivery system consisting of PBA and amino groups at physiological conditions.

Full Text