Abstract
Amyloidosis are a heterogeneous group of diseases in which proteins, usually soluble in plasma, are deposited in the extracellular space and insoluble fibrillar form (amyloid deposition) which will cause damage to organs and tissues. There are two major forms of amyloidosis: the AL or primary, which is associated with plasma cell dyscrasias, and AA or secondary, which is a complication of chronic diseases in which there is a recurring inflammation or maintained as a result of chronic infections, diseases rheumatic or inflammatory bowel disease, tumors, among others.Diagnosis in amyloidosis should not be based solely on clinical, histological confirmation remains essential and characterization of the type of amyloid. Also in AL amyloidosis is important to confirm the evidence of a proliferative disorder of monoclonal plasma cells in AA amyloidosis and the underlying inflammatory disorder. The early and accurate diagnosis of the type of deposit is crucial in the prognosis and treatment selection, which will vary according to the amyloid precursor protein.
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