Abstract
One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A–F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua. The structures of the undescribed compounds were elucidated based on the analysis of 1D and 2D NMR and MS data. Furthermore, the structures of pipermullesines A–C were confirmed by single crystal X-ray diffraction analysis. All isolates were evaluated for inhibitory activity against platelet aggregation induced by thrombin (IIa) or platelet-activating factor (PAF). (-)-Mangochinine, pellitorine, and (2E,4E)-N-isobutyl-2,4-dodecadienamide showed weak inhibitory activity against rabbit platelet aggregation induced by PAF, with IC50 values of 470.3 µg/mL, 614.9 µg/mL, and 579.7 µg/mL, respectively.Graphical
Highlights
One undescribed amide, pipermullesine A, two undescribed isoquinoline alkaloids, pipermullesines B and C, and six undescribed dipeptides, pipermullamides A–F, along with 28 known compounds, were isolated from the aerial parts of Piper mullesua
Antiplatelet compounds have been found in a Huoxue herb Selaginella moellendorffii Hieron. (Selaginellaceae) [2, 3]
The genus Piper (Piperaceae) is a medicinally important group of plants consisting of approximately 2000 species worldwide
Summary
Traditional Chinese medicines with the functions of promoting blood circulation (“Huoxue” in Chinese) and/ or removing blood stasis (“Huayu” in Chinese) are claimed to be useful in antiplatelet therapies and the treatment of thrombotic diseases [1]. The genus Piper (Piperaceae) is a medicinally important group of plants consisting of approximately 2000 species worldwide. Some Piper species are used for promoting blood circulation, while Piper mullesua Buch.-Ham. ex D. As a folk medicine in China with the Chinese name of Duan-Jv (短蒟), the whole plants of P. mullesua are used to treat bleeding, bone fractures, injuries from falls, rheumatoid arthritis, rheumatic arthralgia, acroanesthesia, asthma, colds, stomach aches, abdominal pain, toothaches, swelling and pain of furuncles, dysmenorrhea, menoxenia, empyrosis, and snake and insect bites [5, 6]. In continuing efforts to search for antiplatelet compounds from Piper plants [12, 13], we present the results of the analysis of compounds from the aerial parts of P. mullesua and the bioactivity of these compounds
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