Amides from the Roots of Toddalia asiatica

Abstract

A chemical investigation of the ethanol extract from the roots of Toddalia asiatica resulted in the isolation of three new amides, (7Z)-N-(4′-methoxyphenethyl)-3-methoxy-4-hydroxycinnamamide ( 1 ), (7Z)-N-(4′-hydroxyphenethyl)-3-methoxy-4,5-dihydroxycinnamamide ( 2 ), and (7E)-N-(4′-hydroxyphenethyl)-3,4,5-trihydroxycinnamamide ( 3 ), together with one known amide (7Z)-N-(4′-hydroxyphenethyl-3-methoxy-4-hydroxycinnamamide ( 4 ). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses.