AMH Serum Level as a Predictor of In Vitro Fertilization (IVF) Parameters [3B

Abstract

INTRODUCTION: Anti-müllerian hormone (AMH) serum level is a component of the infertility workup to evaluate ovarian reserve. Diminished ovarian reserve is one of the major causes of female infertility. Our study examines the relationship between AMH serum level and IVF success. METHODS: We performed a retrospective cohort study at a single academic institution, including 145 patients undergoing 185 IVF cycles. The IVF outcomes were reviewed for completed cycles within 12 months of collected follicle stimulating hormone (FSH) and AMH serum levels, under an exempt IRB in 2012. Data included number of oocytes retrieved, number of mature oocytes, number of oocytes fertilized, number of cleavage stage embryos, number of embryos transferred, number of embryos frozen, and number of embryos discarded. The Shapiro-Wilk test of normality and Spearman’s rank correlation coefficient were used for statistical analysis with p<0.05. RESULTS: There is a positive correlation between AMH serum level and the number of oocytes retrieved, the number of mature oocytes, the number of fertilized oocytes, and the number of cleavage stage embryos. These findings are statistically significant. There is no correlation between AMH serum level and embryo quality. CONCLUSION: AMH serum level correlates with certain IVF parameters, including oocytes retrieved and the number of cleavage stage embryos. AMH serum level does not predict embryo quality. However, an IVF cycle with an increased number of retrieved and fertilized oocytes is likely to have a higher chance of resulting in embryos preferable for transfer in a current or future cycle.