Abstract
BackgroundFormula is an important means of traditional Chinese medicine (TCM) to treat diseases and has great research significance. There are many formula databases, but accessing rich information efficiently is difficult due to the small-scale data and lack of intelligent search engine.MethodsWe selected 38,000 formulas from a semi-structured database, and then segmented text, extracted information, and standardized terms. After that, we constructed a structured formula database based on ontology and an intelligent retrieval engine by calculating the weight of decoction pieces of formulas.ResultsThe intelligent retrieval system named AMFormulaS (means Ancient and Modern Formula system) was constructed based on the structured database, ontology, and intelligent retrieval engine, so the retrieval and statistical analysis of formulas and decoction pieces were realized.ConclusionsAMFormulaS is a large-scale intelligent retrieval system which includes a mass of formula data, efficient information extraction system and search engine. AMFormulaS could provide users with efficient retrieval and comprehensive data support. At the same time, the statistical analysis of the system can enlighten scientific research ideas and support patent review as well as new drug research and development.
Highlights
Formula is an important means of traditional Chinese medicine (TCM) to treat diseases and has great research significance
AMFormulaS is a large-scale intelligent retrieval system which includes a mass of formula data, efficient information extraction system and search engine
Knowledge of formulas is mainly recorded in diverse TCM books which results in the difficulties of retrieval and acquirement
Summary
Formula is an important means of traditional Chinese medicine (TCM) to treat diseases and has great research significance. The form of node-edgenode could only show the most important information by some terms rather than complete sentences, which might consult information loss; Shen et al.structured the listed proprietary Chinese medicine data and built the Chinese patent medicine database which integrated patent medicine information, but the patent medicine information was not sufficient for academic and clinical research [12; Ruichao Xue et al constructed a traditional Chinese medicine integrative database to integrate the traditional Chinese medicine and western medicine which included some TCM knowledge, like formula, TCM drugs, and herbal ingredients This database mainly focused on the herb molecular mechanism analysis, and didn’t meet the needs of other formula research [13]
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