Abstract
The annual American Society of Clinical Oncology congress is the largest forum for cancer professionals in the world, promoting new developments in cancer medicine. A wide spectrum of subjects relevant to breast cancer research and treatment was covered in this year's meeting, including chemotherapy in the neoadjuvant and adjuvant settings, molecular and gene profiling studies, and use of more conventional prognostic and predictive markers of outcome. This report discusses some of the highlights in translational and clinical aspects of early breast cancer management presented at the meeting.
Highlights
The American Society of Clinical Oncology (ASCO) Annual Meeting is a leading educational and scientific event for oncologists, clinical researchers, academics and other health care professionals involved in multidisciplinary cancer care
The first presentation in the meeting’s plenary session, given by Lajos Pusztai from the MD Anderson group, dealt with the predictive nature of profiling in terms of response to chemotherapy. Their group described the use of gene expression profiling in predicting complete pathological response to neoadjuvant chemotherapy with a paclitaxel and anthracycline combination
The National Epirubicin Adjuvant Trial (NEAT) trial was presented by Dr Chris Poole from the Cancer Research UK Institute and Cancer Trials Unit in Birmingham. This is the first of the large adjuvant chemotherapy trials to come from the UK, and shows a very significant advantage for epirubicin, cyclophosphamide, methotrexate and fluorouracil (ECMF) chemotherapy in terms of both disease-free and overall survival when compared with standard classical cyclophosphamide, methotrexate and fluorouracil (CMF) for six cycles
Summary
The American Society of Clinical Oncology (ASCO) Annual Meeting is a leading educational and scientific event for oncologists, clinical researchers, academics and other health care professionals involved in multidisciplinary cancer care. Their group described the use of gene expression profiling in predicting complete pathological response (pCR) to neoadjuvant chemotherapy with a paclitaxel and anthracycline combination (abstract #1 [1]). Patients with stable or progressive disease following standard anthracycline-based neoadjuvant chemotherapy were treated with weekly 5-fluorouracil, gemcitabine and dexamethasone during radiotherapy to the breast (50 Gy with 10 Gy boost).
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