American Confederation of Urology (CAU) experience in minimally invasive partial nephrectomy.

Abstract

To describe the perioperative and oncology outcomes in a series of laparoscopic or robotic partial nephrectomies (PN) for renal tumors treated in diverse institutions of Hispanic America from the beginning of their minimally invasive (MI) PN experience through December 2014. Seventeen institutions participated in the CAU generated a MI PN database. We estimated proportions, medians, 95% confidence intervals, Kaplan-Meier curves, multivariate logistic and Cox regression analyses. Clavien-Dindo classification was used. We evaluated 1501 laparoscopic (98%) or robotic (2%) PNs. Median age: 58years. Median surgical time, warm ischemia and intraoperative bleeding were 150, 20min and 200cc. 81% of the lesions were malignant, with clear cell histology being 65% of the total. Median maximum tumor diameter is 2.7cm, positive margin is 8.2%, and median hospitalization is 3days. One or more postoperative complication was recorded in 19.8% of the patients: Clavien 1: 5.6%; Clavien 2: 8.4%; Clavien 3A: 1.5%; Clavien 3B: 3.2%; Clavien 4A: 1%; Clavien 4B: 0.1%; Clavien 5: 0%. Bleeding was the main cause of a reoperation (5.5%), conversion to radical nephrectomy (3%) or open partial nephrectomy (6%). Transfusion rate is 10%. In multivariate analysis, RENAL nephrometry score was the only variable associated with complications (OR 1.1; 95% CI 1.02-1.2; p=0.02). Nineteen patients presented disease progression or died of disease in a median follow-up of 1.37years. The 5-year progression or kidney cancer mortality-free rate was 94% (95% CI 90, 97). Positive margins (HR 4.98; 95% CI 1.3-19; p=0.02) and females (HR 5.6; 95% CI 1.7-19; p=0.005) were associated with disease progression or kidney cancer mortality after adjusting for maximum tumor diameter. Laparoscopic PN in these centers of Hispanic America seem to have acceptable perioperative complications and short-term oncologic outcomes.