Amenorrhea in Russell-Silver syndrome calls for an early gynecological intervention

Abstract

There has been considerable research on Russell-Silver Syndrome (RSS) which has an incidence of 1 in 30,000 to 1 in 100,000 people. Although numerous case reports have been published on children with RSS, very few have emphasized on adults. In this case report, we present a case of RSS in a 22-year-old women who presented with amenorrhea and abdominal pain. Normal menstrual cycle and normal estrogen level are necessary for bone health, lipid profile, cardiovascular health and mental health. An early intervention will thus help to reverse the effects of irregular menstrual cycles on long term health and address other causes like premature ovarian failure. The purpose of this report is to invite researchers to investigate whether there is a correlation between RSS and menstrual abnormalities, in which case early screening for ovarian and genital tract abnormalities in RSS will help to address the reproductive issues before a permanent consequence develops.