Amenorrhea After Medroxyprogesterone

Abstract

To the Editor:— The article, Irregular Menses, Amenorrhea, and Infertility Following Synthetic Progestational Agents, by Whitelaw, Nola, and Kalman (195:780, 1966) was of particular interest because of the report of seven patients with amenorrhea given medroxyprogesterone acetate (Depo-Provera) intramuscularly. Of 15 patients with amenorrhea following the use of progestational agents, seven had received this drug. Since it is prescribed much less frequently than the oral progestational agents which the other patients in the report had received, the incidence of amenorrhea following the use of medroxyprogesterone would appear to be higher than that following the use of other progestational agents. Amenorrhea following the intramuscular administration of medroxyprogesterone acetate accounts for a considerable fraction of the patients with amenorrhea seen recently in our infertility clinic. Of 145 patients with amenorrhea or oligomenorrhea seen at the Stanford Clinic between January 1963 and August 1965, amenorrhea had developed in six following injections of