AMELOBLASTOMA WITH ADENOID STRUCTURES: A SURVEY OF 6 NEW CASES

Abstract

<h3>Objectives</h3> The aim of the present study was to analyze the clinicopathologic profile of ameloblastomas with adenoid structures. <h3>Study Design</h3> This retrospective observational study consisted of cases diagnosed as ameloblastoma between 2014 and 2021 that were microscopically reviewed. The included cases were only those exhibiting focal (<50% of the tumor) or predominant (>50% of the tumor) duct-like spaces of variable size, lined by cuboidal to columnar cells containing mucoid material. Clinical data were collected from biopsy request forms and tabulated for descriptive analyses. <h3>Results</h3> There were 125 ameloblastomas (1.2%; ∼15 cases per year). Adenoid structures were observed in 6 samples (4.8%) from 5 males and 1 female, with a mean age of 41 years (range, 25 to 61). The posterior region of the mandible was most frequently affected (<i>n</i> = 5). The cases presented as asymptomatic unilocular (<i>n</i> = 1) or multilocular (<i>n</i> = 4) radiolucency. Three cases exhibited predominant adenoid structures, 1 of which exhibited exuberant dentinoid material. The other 3 cases of conventional ameloblastoma showed focal areas of adenoid features. <h3>Conclusions</h3> Adenoid structures in ameloblastoma appear to be an uncommon event of unknown clinical significance and may be associated with dentinoid material and should not be misinterpreted as an adenomatoid odontogenic tumor.