Abstract
The present study evaluates the anticonvulsant activity of the roots of Anacyclus pyrethrum using pilocarpine-induced experimental model of epilepsy in rat, and to determine its possible anticonvulsant mechanism. Ethanol extract (200 and 400 mg/kg) or alkylamides (25 and 50 mg/kg) was administered orally 45 min before the injection of pilocarpine-induced (400 mg/kg) seizures. The possible anticonvulsant mechanism was investigated by testing the effect of atropine (2 mL/kg) and scopolamine (1 mg/kg). The scoring of seizure severity, seizures time latency, duration of total seizures and percentage of mortality protection were recorded. Ethanol extract and alkylamides prolonged the time of onset seizure and decreased the duration of seizures compared to control group (p<0.001). The seizure protection was 100%. The co-administered of ethanol extract of A. pyrethrum and alkylamides with atropine completely abolished the pilocarpine-induced seizures.
 Video Clip of Methodology:
 Anticonvulsant effect: 6 min 7 sec: Full Screen Alternate
Highlights
Epilepsy is known as one of the most prevalent and severe neurological disorders
No visible sign or symptom of toxicity in mice was observed after oral administration of A. pyrethrum ethanol extract
The findings showed that the ethanol extract of A. pyrethrum and alkylamides significantly reduced the duration of seizures and increased the latency period of pilocarpineinduced seizures in rats
Summary
Antiepileptic drugs are prescribed alone or in combination as a means of curing epilepsy (Hernan and Holmes, 2016). These antiepileptic drugs, in most cases, cause one or more secondary effects (Kaur et al, 2016). To overcome these problems, several studies conducted in recent years have supported the use of herbal remedies as alternatives. Animal studies have shown that several plants such as Abies webbiana (Parkash et al, 2015), Artemisia persica (Daneshkhah and Setorki, 2019), Carum carvi (Showraki et al, 2016), Citrus sinensis (Citraro et al, 2016), Crocus sativus (Khazdair et al, 2015), Dodonaea viscosa (Karim et al, 2015), Kalanchoe pinnata (Mora-Pérez and Hernández-Medel, 2016), Laggera aurita (Malami et al, 2016), and Silybum marianum (Waqar et al, 2016) have anticonvulsant effect over experimental models of epilepsy
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