Abstract
The aim of the present study was to investigate the nephroprotective, hypolipidemic and hypoglycemic effects of Allium porrum (leek) in rabbits with cisplatin nephrotoxicity. Forty adult male New Zealand rabbits were divided randomly into four groups (ten rabbits in each group) as follows: Group I: (negative control) (C) received oral daily dose of distilled water for 15 successive days. Groups II: (Leek) (L) received oral daily dose of aqueous leek extract (500mg/kg/day) for 15 successive days. Group III: (positive control) [cisplatin (CP)] received oral daily dose of distilled water for 15 successive days, and subsequently administered single dose of Cisplatin (3.5mg/kg/day) by intraperitoneal injection from day 10 for five days. Groups IV: (Leek and Cisplatin
Highlights
TableCisplatin is an anticancer drug with a high preference; commonly used as a first line therapy against solid tumors such as the head and the neck, ovarian, and testicular carcinoma
The renal cortical GSH was measured by the method of Sedlak and Lindsay [12] and the amount of lipid peroxidation was measured as thiobarbituric acid reactive substance (TBARS) according to the method of Walter et
Cisplatin treatment is known to be associated with depletion of the renal antioxidant defense system which is implicated as the main causes of cisplatin induced nephrotoxicity [15]
Summary
TableCisplatin is an anticancer drug with a high preference; commonly used as a first line therapy against solid tumors such as the head and the neck, ovarian, and testicular carcinoma. Mechanisms of cisplatin-induced nephrotoxicity are believed to involve the generation of oxygen free radicals and oxidative stress [3]. This is known to induce the DNA damages and produces inflammatory cytokines that proceed into renal injury [4]. Several medicinal plants are rich in potent antioxidant agents, and many have been tested as protective agents against drug-induced nephrotoxicity [5,6]. Porrum ( known as Allium porrum Family, Liliaceae), and commonly named leek is a plant used as food that contains excellent amounts of polyphenols, trace minerals and phytochemicals, and the plant has hypolipidemic, hypoglycemic and antimicrobial properties[7]. The present study was planned to investigate the possible protective effects of the aqueous extract of Wild Leek against the cisplatininduced nephrotoxicity and dyslipidemia in the rabbit
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