Ameliorative Effects of Curcumin on Aflatoxin B1-Induced Nephrotoxicity in Wistar-Albino Rats

Abstract

Mycotoxins exposed through food can lead to organ dysfunction and even failure. The number of studies on renal failure induced by aflatoxin B1 (AFB1) is limited. The purpose of this trial was to examine the effect of AFB1 on the kidney and whether its possible deleterious effect could be prevented by curcumin, a traditionally used and economical antioxidant. 38 rats were divided into five groups, group I represented the control, while the others were named dimethylsulfoxide, curcumin, AFB1, and AFB1 + Curcumin, respectively. Plasma samples were taken from each group after 60 days. Then, BUN, uric acid, and creatinine levels were determined by the ELISA method. Data were analyzed statistically. Bodyweight gain at the end of the study was the least in the group administered AFB1. Also, BUN, uric acid, and creatinine levels were higher in this group than in the other groups. Concomitant administration of AFB1 and curcumin improved both body weight gain and BUN, uric acid, and creatinine levels. Therefore, curcumin can be considered as a low cost-high efficacy renal protective agent in the prevention of renal failure caused by mycotoxins, especially AFB1.