Abstract
The present study was designed to evaluate the Pharmacological effects of Anacardic acid in Letrozole induced polycystic ovary syndrome in female Albino wistar rats. Rats were administered with Letrozole (1mg/kg in 0.5% CMC, p.o.) for 21 days to induced PCOS characterized by hyperandrogenism, dyslipidemia and development of numerous subcapcular cysts in the ovaries. Letrozole treated animals showed significant decrease in serum progesterone, Estradiol, FSH, and LH Levels, antioxidants like GSH, Catalase, TBARS, and ovarian weights. After 21 days PCOS induced rats were administered with [Low dose (10mg/kg) and high dose (40mg/kg), p.o.] of Anacardic acid for next 15 days. Anacardic acid treatment decreased testosterone normalized anti-oxidant levels and also reduced cysts in ovaries and induced ovulation. These results suggest that Anacardic acid attenuates PCOS through maintaining sex hormones levels, antioxidant activities.
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