Abstract
Ameliorative Effect of Vitamin E on Azithromycin Induced Biochemical and Histological Changes in Liver Tissue of Rats
Highlights
Azithromycin is a macrolide antibiotic recommended as first line therapy for prophylaxis and treatment of disseminated infection caused by Mycobacterium avium intracellulare in AIDS patients and for the treatment of pulmonary disease in non-HIV infected patients (Kovacs and Masur, 2000; Rao et al, 2014)
Though the enzyme activity significantly increased in both pretreated and posttreated groups compared to azithromycin treated group, the activity in pretreated group was comparable to vitamin E alone treated group
It was observed that treatment with azithromycin reduced the activities of tissue ALT, AST, alkaline phosphatase (ALP), superoxide dismutase (SOD) and CAT compared to the control
Summary
Azithromycin is a macrolide antibiotic recommended as first line therapy for prophylaxis and treatment of disseminated infection caused by Mycobacterium avium intracellulare in AIDS patients and for the treatment of pulmonary disease in non-HIV infected patients (Kovacs and Masur, 2000; Rao et al, 2014). Though it was considered as a safe drug with mild gastrointestinal symptoms and skin rashes (Leclercq, 2002), high doses employed for the treatment of Mycobacterium avium complex caused tinnitus, dizziness and reversible hearing loss (Wallace et al, 1994; Lin et al, 2010). Oxidative stress has been found to be an important mechanism in hepatotoxicity ( Jaeschke et al, 2002; Amin and Hamza, 2005; Di Sario et al, 2007; Cheung and Sanyal, 2010; Jaeschke and Ramachandran, 2011)
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