Ameliorative effect of trigonelline in restraint stress-induced behavioral alterations in mice

Kaur Prabhjot,Kaur Amarjot,Singh Thakur Gurjeet,Dhiman Sonia,Arora Sandeep

doi:10.7324/japs.2021.11s106

Abstract

Ameliorative effect of trigonelline in restraint stress-induced behavioral alterations in mice

Highlights

Stress is a significant rising problem among modern society growing under uncertain disruptive environmental situations affecting human health
The current research was designed to evaluate the anti-stress ability of trigonelline in behavioral and biochemical changes caused by restraint stress in mice
Administration of trigonelline (25 and 50 mg/kg i.p.) and diazepam (2 mg/kg, i.p.) significantly (p < 0.05) and dose-dependently attenuated restraint stress-induced anxiety like behavior as measured in terms of the average time spent in the open arm and number of entries when compared with stress control group (Figs. 1 and 2)

Summary

Introduction

Stress is a significant rising problem among modern society growing under uncertain disruptive environmental situations affecting human health. Stress attributes a negative impact on human life and affects other living organisms which are frequently being exposed to variant intrinsic and extrinsic stressful stimuli, and contributing to the distortion of physiological. When the body is exposed to stress stimuli, it persuades a variety of alterations such as changes in exudation of hormones, adrenocorticotropic hormone (ACTH), autonomic function of the body, and behavior (Kar et al, 1999). Prolonged contact with stress has been observed to prompt depression (Willner et al, 1998) and behavioral changes in animal models (Swiergiel et al, 2007) and human beings (Van Praag, 2004)

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Discussion

Conclusion