Abstract
Sphenostylis stenocarpa is a legume crop of Fabaceae family. Several studies have shown that the seeds are rich in chemical constituents capable of suppressing benign prostatic hyperplasia (BPH). The purpose of this study was to investigate effect of the seed extracts on experimentally induced BPH in rats. Thirty five male Wistar rats were randomized into seven groups of five rats each. BPH was induced in the rats by subcutaneous injection of testosterone propionate for 28 days and thereafter treated with ethanolic and petroleum ether extracts of the plant seeds at different doses (200 and 400 mg/kg body weight) for seven days. The effect of the extracts on BPH parameters and antioxidant indices were studied. Finasteride was used as a positive control. The results showed that treatment of the disease rats with 400 mg/kg body weight of the extracts resulted in a significant decrease (p S. stenocarpa seed could be useful in management of BPH.
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