Abstract
Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in inflammatory bowel diseases. The present study was designed to evaluate the effect of feeding low-fat probiotic yogurt containing <i>L. acidophilus</i> and <i>L. bulgaricus</i> on acetic acid-induced inflammation in mouse colon. Inflammatory model that mimics various features of IBDs was induced by a single application of 100µl of 4.5% acetic acid in Swiss Albino mice. Mice were pretreated orally by 200µl yogurt containing both <i>L. acidophilus</i> and <i>L. bulgaricus</i> for 3 days before induction of inflammation and 200µl yogurt was given orally for a period of 7 days after acetic-acid induction. The body weight, food and water intakes, serum biomarkers, macroscopic and histopathological studies of colon tissues were performed to evaluate the anti-inflammatory effect. Combined administration of both strains prevented the damages of villous and crypts in colon epithelial cells and thus provides unique mucosal protective effects in experimental colitis. In conclusion, feeding low-fat probiotic yogurt containing <i>L. acidophilus</i> and <i>L. bulgaricus</i> prevented or ameliorated the inflammatory conditions that can be beneficial to prevent or lower risks of IBDs and its complications.
Highlights
Inflammatory bowel diseases (IBDs), which comprise ulcerative colitis (UC) and Crohn’s disease (CD), affect the gastrointestinal tracts (GIT) with chronic and relapsing inflammation
Gut microbiota plays a crucial role in triggering, maintaining, and exacerbating IBDs. The etiology of these diseases is still unclear, the main hypothesis is that IBDs are a result of an excessive immune response to endogenous bacteria, which occurs in genetically predisposed individuals [1, 2]
We aimed to investigate the antiinflammatory effect of two lactobacillus strains, L. acidophilus and L. bulgaricus in acetic acid-induced mouse model by analyzing the histopathological studies of the mouse colon
Summary
Inflammatory bowel diseases (IBDs), which comprise ulcerative colitis (UC) and Crohn’s disease (CD), affect the gastrointestinal tracts (GIT) with chronic and relapsing inflammation. A well balanced diversity of intestinal microbiota is an important aspect of health. Potentially pathogenic bacteria are kept under control by the non-pathogenic flora, so called colonization resistance. Gut microbiota plays a crucial role in triggering, maintaining, and exacerbating IBDs. the etiology of these diseases is still unclear, the main hypothesis is that IBDs are a result of an excessive immune response to endogenous bacteria, which occurs in genetically predisposed individuals [1, 2]. Epithelial integrity of the gut is essential for preventing the invasion of microorganisms and the development of inflammation in intestinal submucosa. The intestinal epithelium is a highly selective barrier that permits the absorption of nutrients from the gut lumen into the circulation and at the same time restricts the passage of harmful and potentially
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