Abstract
Abstract The effects of soy extract fermented by Lactobacillus plantarum WW (L. plantarum WW) on high fat diet (HFD)-induced hyperlipidemia and liver injury were examined. Sprague-Dawley rats were randomly divided into normal chow (C), HFD and HFD + L. plantarum WW-fermented soy extract (HFD + FSE). We found that L. plantarum WW-FSE treatment significantly restored changes to body weight and pathological indices caused by fatty liver disease. RNA-seq analysis showed that treatment with L. plantarum WW-FSE altered expression of genes involved in lipid metabolism, and in oxidation-reduction processes. This study supported that the peroxisome proliferator-activated receptor (PPAR) signaling pathway may be involved in lipid metabolism, and suggested that dietary L. plantarum WW-FSE ameliorates HFD-induced lipid metabolism disturbance in rat liver associated with PPAR signaling pathway. These observations shed new light on possible treatment of hyperlipidemia.
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