Abstract
Ameliorative Effect of Garden Cress (Lepidium sativum L.) Seeds Ethanolic Extract on High Fat Diet-prompted Non-alcoholic Fatty Liver Disease in the Rat Model: Impact on 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase and Vascular Endothelial Growth Facto
Highlights
The liver is responsible for lipid metabolism (HenaoMejia et al, 2012)
While assessing hepatic oxidative stress status, and expression of HMGCR and vascular endothelial growth factor A (VEGF) mRNA, this study explored the hepato-ameliorative effect of ethanolic extract of garden cress seeds (EEGS) in rat non-alcoholic fatty liver disease (NAFLD) model.The phytochemical screening of EEGS was carried out to determine the contents of total phenolic, flavonoids, vitamin C, and elucidate DPPH radical scavenging activity
NAFLD model was established by high-fat diet (HFD) that consisted of standard diet (355 gm/kg), lard (310 gm/kg), casein (250 gm/kg), cholesterol (10 gm/kg), corn oil (10 gm/kg), DL-Methionine (3 gm/kg), vitamins and mineral mix (60 gm/kg), sodium chloride mix (1 gm/kg), and yeast powder (1 gm/kg) (Srinivasan et al, 2005)
Summary
The liver is responsible for lipid metabolism (HenaoMejia et al, 2012). The non-alcoholic fatty liver disease (NAFLD) develops by an accumulation of excrescent hepatic fat without the intake of excessive alcohol. Feeding on the high-fat diet (HFD) results in hepatic redox imbalance mediating lipid peroxidation that promotes the progression of NAFLD (Rolo et al, 2012; Kakimoto and Kowaltowski, 2016). Garden cress (Lepidium Sativum L.) belongs to the Brassicaceae family and is native to Egypt and West Asia. It possesses proteins, vitamins, carbohydrates, omega-3 fatty acids, iron, phytochemicals, and flavonoids (Nehdi et al, 2012; Emhofer et al, 2019).
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