Ameliorative Effect of Cerium Oxide Nanoparticles against Cadmium Nephrotoxicity in Male Albino Rats

Mostafa Bashandy,Olfat Shehata,Hanan Saeed,Walaa Ahmed,Marwa Ibrahim

doi:10.21608/jvmr.2021.105032.1045

Abstract

Ameliorative Effect of Cerium Oxide Nanoparticles against Cadmium Nephrotoxicity in Male Albino Rats

Highlights

Humans presented to the cadmium toxicity through consumption of rice because cadmium once released into the free environment, collected in crops and afterward enters the food chain, which prompts adverse effects for environmental and human wellbeing (Shi et al 2020)
In cerium oxide nanoparticles treated groups (V and values in the group (VI)), they adverse the oxidative stress induced by the cadmium toxicity through a significant decrease of the MDA level and significant increase of the superoxide dismutase (SOD) and GSH levels when compared to the cadmium group
The present results indicated that the kidney was affected by Cd, since urea and creatinine levels were significantly increased in CdCl2-treated rats throughout the experiment in comparable with groups (I, II and in comparison with the group (III))

Summary

Introduction

Humans presented to the cadmium toxicity through consumption of rice because cadmium once released into the free environment, collected in crops and afterward enters the food chain, which prompts adverse effects for environmental and human wellbeing (Shi et al 2020). Administration of cerium oxide nanoparticles led to non-significant changes in the erythrogram when compared to both groups (I, II and III) and group (IV) at the 21st and 28th days (Table 1).

Results

Conclusion