Abstract
ABSTRACT
 The aim of the study is to assess the effect of aqeueous extract of bitter leaf on egg yolk induced kidney toxicity in adult wistar rat. A total of 44 (forty four) adult wistar rats weighing between 220 g to 250 g were separated into 4 groups of 11 rats per group. Group A rats were placed on normal diet only while Group B rats received 300 mg/ kg body weight / day (BWT/D) of egg yolk. Group C rats received 250mg / kg BWT/D of bitter leaf. Group D rats received 300 mg/ kg BWT/D of egg yolk and 250mg / kg BWT/D of bitter leaf. The dosage were given for 32 days via orogastric method. The biochemical outcome showed that group B revealed marked elevation in the urea, SOD, cholesterol level when compared with the other groups. Histologically, group B showed a mild vascular obstruction and patchy tubular necrosis, while group A, C and D revealed normal architecture of the kidney. We can therefore concluded that the aqueous extract of bitter leaf have antioxidative and neproprotective properties against egg yolk induced kidney toxicity in wistar rat.
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