Abstract
BackgroundHigh lipophilicity and poor aqueous solubility are the endemic problems of new drug molecules. Sixty to seventy percent of these drugs are unable to solubilize completely in aqueous media, or have very low permeability. This hampers their oral absorption and further leads to their poor bioavailability. Various researches are in progress to overcome these limitations. Novel technologies like nano-carrier systems have become popular for improving the solubility of drugs.Main bodyLipid-based formulations, among nano systems, are taking pace for the enhancement of solubility, oral absorption, and hence the bioavailability of drugs. Among the lipid formulations, self-emulsification systems are gaining popularity by offering various advantages to delivery systems. Self-emulsifying drug delivery systems (SEDDS) are isotropic blends of oil and surfactant/co-surfactants. These ingredients upon gentle agitation in aqueous media results in the formation of o/w emulsion. In spite of many works published in SEDDS, the major concerns of this article are to discuss the various approaches to formulate a good lipid-based carrier system for poorly aqueous soluble drugs, role of various polymers, and their categories used in the formulation along-with the modern technologies used for enhancing the stability of liquid SEDDS. This review majorly focuses upon the problems related to the poor aqueous solubility of the newer lipid molecules and the solutions to overcome their solubility and in addition bioavailability.ConclusionAs per the researches done in formulation and optimization of SEDDS for the enhancement of bioavailability of lipophilic molecules, it can be stated that the aqueous solubility as well as bioavailability can be increased by many folds compared to their marketed or other oral formulations.
Highlights
It is possible to enhance the oral bioavailability and reduce the probable side effects of an active pharmaceutical ingredient with lipid-based carrier systems
The medications are commonly administered orally; around 40% of new drug competitors have poor-water solvency and the oral delivery of such medications is troublesome in view of their low bioavailability, high intra- and inter-subject fluctuation, and an absence of dose proportionality [1, 2]
Poor aqueous solubility and low dissolution rate are the major cause of inadequate oral bioavailability of lipophilic drugs [4, 5, 7]
Summary
As stated in the literature and with a brief review, it can be said that SEDDS is a better approach for the formulation and development of delivery systems for low solubility and/or low permeability drugs, to facilitate their dissolution and absorption. The process of manufacturing is excellent and simple and with the use of conventional and commonly available equipments. PG, Plurol Oleique, and drug delivery system of drug myristate, soybean oil, Lauroglycol 90/ethanol,. Delivery systems increased due to greater formed by spontaneous solubilization in mixed emulsification micelles. Delivery systems formed by can measure the emulsification spontaneous emulsification of SEDDS
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