Abstract
Amaranthus graecizans subsp. silvestris, a folk medicine for the treatment of inflammation, was used to evaluate its hepatoprotective potential against rifampicin and isoniazid-induced liver damage. Wistar albino rats were divided into four groups: Group I served as control (distilled water treated), Group II served as hepatotoxic group (isoniazid 50 mg/kg and rifampicin 100 mg/kg, treated), Group III served as positive control (silymarin 100 mg/kg, treated) while Group IV served as A. graecizans subsp. silvestris extract (400 mg/kg) treated group. The results suggest that the liver markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin) were significantly increased in the animals of Group II. The methanolic extract showed a significant decrease in the raised liver enzymes of Group IV and encountered the liver damage caused by isoniazid and rifampicin. Histopathological examination of liver also revealed the improved architecture in the extract-treated group. Thus, the methanolic extract has potential liver protective action due to its phytochemicals.
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Highlights
Observed treatment short course (TB–DOTS) with isoniazid, rifampicin and pyrazinamide are highly effective treatment for the management of tuberculosis
Parenchymal cells are primary cells subjected to oxidative stress-induced injury in the liver (Li et al, 2015). It plays a core role in liver aberrations and their progression, the utilization of herbal drugs with anti-oxidant potentials have been suggested as healing agents, as well as adjuncts, to neutralize liver damage (Casas-Grajales and Muriel, 2015)
Methanolic extract of A. graecizans subsp. silvestris was evaluated for its hepatoprotective potentials against the combination of isoniazid and rifampicin
Summary
Observed treatment short course (TB–DOTS) with isoniazid, rifampicin and pyrazinamide are highly effective treatment for the management of tuberculosis. Silvestris (Vill.) Brenan, known as “Mediterranean amaranth”, belongs to the family Amaranthaceae, occurs in the warmer parts of Europe to the cooler regions of Western Asia and North Western India, found in tropical Africa (Flora of Pakistan, 1972) It is considered as a wild food plant, semi-cultivated in Africa and consumed as a vegetable (Tabuti, 2007). Parenchymal cells are primary cells subjected to oxidative stress-induced injury in the liver (Li et al, 2015) As, it plays a core role in liver aberrations and their progression, the utilization of herbal drugs with anti-oxidant potentials have been suggested as healing agents, as well as adjuncts, to neutralize liver damage (Casas-Grajales and Muriel, 2015). The present project was designed to evaluate hepatoprotective potential of Amaranthus graecizans subsp. silvestris, against isoniazid and rifampicin-induced liver toxicity in Wistar rats
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