Amelioration of Cyclophosphamide-Induced Hepatotoxicity by the Brown Seaweed Turbenaria ornata

Abstract

The present study was designed to investigate the possible protective effects of the brown seaweed, Turbenaria ornata, against cyclophosphamide (CP)-induced hepatotoxicity in rats. The biochemical results showed that administration of CP induced hepatic damage associated with a significant increase in the serum marker enzymes aspartate and alanine transaminases (AST, ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). In addition, CP induced oxidative stress in the liver as evident from the increased lipid peroxidation (LPO), declined glutathione (GSH) content and glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities. Moreover, administration of CP was associated with a significant decrease in serum adiponectin level and an increase in serum tumor necrosis factor alpha (TNF-I±). Concomitant administration of Turbenaria ornata extract efficiently alleviated the altered biochemical parameters. In conclusion, Turbenaria ornata extract showed a marked hepatoprotective effect against CP-induced hepatotoxicity through alleviation of the declined serum adiponectin in addition to its antioxidant and anti-inflammatory efficacies.