Abstract
In the current study, we investigated the therapeutic potential and underlying mechanisms of the saponin fraction from anomalous fruits of Gleditsia sinensis. Lam. (Leguminosae) (SFGS) on collagen II (CII)-induced arthritis (CIA) in DBA/1 mice. SFGS (50, 100, and 200 mg/kg), orally administered from the day of immunization, dose-dependently alleviated disease severity, postponed the onset and reduced the incidence rate of CIA. Histologic analysis revealed that joints of CIA mice treated with SFGS showed low inflammatory cell infiltration and slight synovium hyperplasia and focal bone erosion. Furthermore, SFGS treatments lowered the serum anti-CII autoantibody levels and suppressed the delayed-type hypersensitivity against CII in the ears of CIA mice. The findings indicated that SFGS ameliorated inflammation and joint destruction in CIA mice, which may be the consequence of suppression on CII-specific humoral and cellular immunity. SFGS should be a candidate novel therapeutic agent for rheumatoid arthritis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
