AMBULATORY CENTRAL BLOOD PRESSURE OBTAINED BY BPLAB IS QUESTIONABLE

Abstract

Objective: Reference intervals of ambulatory (24-h) central blood pressure (ACBP) obtained from large healthy population are lacking in Russia. ACBP and 24-h BP amplification percentile for each age would be potentially useful for medical practice. This was an attempt to obtain reference values. Design and method: Database consisted of 8987 ABPM files was received by the BPLab device (Russia) during a survey of few districts in Russia. 1st, ABPM-files that corresponded to the normal ambulatory BP according to 2018 ESC/ESH Guidelines for the management of arterial hypertension were selected from database. 2nd, files that indicate antihypertensive treatment, elevated BMI and any disease in extended BPLab-diary were excluded. 3rd, age-specific percentiles ACBP-curves were generated with Vasotens (Russia) and LMS Chartmaker Pro (UK) software. Results: As a result, a selection of 2510 records was suitable for analysis. 24-h BP amplification is shown schematically in the figure below. In the figure: A: Well-known data that are combined from the Framingham Study, from the US National report on high BP in children and adolescents, from the Sydney Group study (2010) and from the Anglo-Cardiff Collaborative Trial II. B: Data from the present study (amplification adapted to a similar systolic pressure). The 24-h BP amplification obtained by the test method is too high, especially in people over the age of 40. Conclusions: The obtained values cannot be recommended for routine medical practice as a reference. The method for calculating central BP used in the device-under-test is likely questionable.