Abstract
An increasing number of studies indicate air pollutants infiltrate into the brain. We aimed to find the association of cumulative air pollution exposure in the main body of primary brain tumor: glioblastoma (GBM). In this double‐cohort, retrospective analysis study with a protocol, we compared the health effect of air pollution on the GBM patients from the SEER (Surveillance, Epidemiology, and End Results Program) in 27 U.S. counties from 10 states and GBM patients of Severance cohort of Korea. From 2000 to 2015, 10621 GBM patients of the SEER were individually evaluated for the cumulative average exposure for each pollutant, and 9444 (88.9%) mortality events were reported. From 2011 to 2018, 398 GBM patients of the Severance with the same protocol showed 259 (65.1%) mortality events. The multi‐pollutant models show that the association level of risk with CO is increased in the SEER (HR 1.252; 95% CI 1.141‐1.373) with an increasing linear trend of relative death rate in the spline curve. The Severance GBM data showed such a statistically significant result of the health impact of CO on GBM patients. The overall survival gain of the less exposure group against CO was 2 and 3 months in the two cohorts. Perioperative exposure to CO may increase the risk of shorter survival of GBM patients of the SEER and the Severance cohort.
Highlights
Accumulation of evidence shows the air pollutants infiltrate into the brain, changes the genetic status of DNA, or may deteriorate oligodendrocytes.[1,2,3,4] we hypothesized that the mortality of brain tumor patients might be associated with air pollution.[5]We focused on the glioblastoma (GBM) patients who are classified as the most vulnerable group among the brain tumor patients.[6]
We aimed to find whether an exposure level within a specific time-window to ambient air pollution is associated with the clinical course of GBM
In addition to the previously known acute highlevel exposures,[17] our study revealed that chronic ambientlevel exposure against carbon monoxide (CO) is associated with a significantly deteriorated survival of patients
Summary
Accumulation of evidence shows the air pollutants infiltrate into the brain, changes the genetic (or epigenetic) status of DNA, or may deteriorate oligodendrocytes.[1,2,3,4] we hypothesized that the mortality of brain tumor patients might be associated with air pollution.[5]We focused on the glioblastoma (GBM) patients who are classified as the most vulnerable group among the brain tumor patients.[6]. After they are discharged from the hospital, the trip of the patient is limited by the severity, emotional distress, brain dysfunction, or comorbidity from the disease.[10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
