Abstract
Objective: Traumatic brain injury (TBI) is a significant socioeconomic and public health problem. Amantadine sulfate has been used as a neuroprotective drug. In this study, We aim that amantadine infusion treatment effects positively in patients with a severe head injury on conscious recovery. Materials and Methods: Patients with TBI were classified into two groups: Patients that used amantadine infusion group was Group I (n=40) and patients that not used amantadine infusion group was Group group II (n=40). Age, gender, Glasgow Coma Scale (GCS), education level, intubated or non-intubated when he/she come to Intensive Care Unit (ICU), the recovery time of conscious, discharge time, recovery of CT or MR scan and Coma Recovery Scale-Revised (CRS-R) were retrospectively recorded. Results: Time to recovery in consciousness was statistically significant shorter in group I. There were no statistically significant differences between the educational status of patients. The GCS of patients, when admitted to ICU, was lower in group I. Functional object use and long-term attention were have higher scores in group I when compared to CRS-R.Conclusion: Amantadine infusion affects positively neurological recovery and neurocognitive function for TBI in this study.
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