Abstract
The objective of present investigation was to improve dissolution of ritonavir (RTV), a BCS Class II drug. Amalgamation of solid dispersion and melt adsorption technology was utilized for developing the formulation. Solid dispersion adsorbate (SDA) was prepared using combination of Lutrol F127, Transcutol HP and Labrasol as carriers and Neusilin as an adsorbent and flow inducer. The concept of design of experiments (DoE) was used in identifying the critical formulation factors. The optimised SDA was characterised by Fourier transform infrared spectroscopy, differential scanning calorimetry, thermogravimetric analysis and X-ray diffraction studies. From the results obtained, it can be concluded that improvement in dissolution of RTV was due to hydrogen bonding of drug with Neusilin, micellar solubilisation of drug in carrier, improved wettability and reduction in the crystallinity. The dissolution efficiency value of optimised SDA is 41.68 % at 10 min time point which is three times the release of untreated drug. Convolution modelling was employed to get a predicted plasma drug concentration time profile.
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