ALZHEIMER’S COGNITIVE IMPAIRMENT CAN BE CURED BY DECREASING BLOOD HOMOCYSTEIC ACID

Abstract

Recent big two clinical trials of amyloid beta treatment for Alzheimer’s disease are all failed to recover the cognitive impairment, it has forced us to reconsider the central hypothesis of amyloid pathogen for Alzheimer’s disease. We recently published that human Alzheimer’s patients showed the strong relationship between Mini Mental State Examination (MMSE) scores and blood homocysteic acid (HA) level. However this relationship did not show the pathogenic action of HA. So we investigated the pathogenic effect of blood HA on MMSE score, that is, how does blood HA level change affect MMSE score? 6 AD patients (all female: age 77, 82, 86,87, 91, 91) were given green tea powder 1g at every meal for 2 months. Their blood HA level and MMSE score were measured before and after taking green tea powder. The relationship between blood HA level change and MMSE score change was investigated. The strong statistically significant negative relationship between blood HA level change and MMSE score change: r=-0.96, p=0.00018, n=6. From our observation, it shows that blood HA level change induced MMSE score change, that is, Alzheimer’s cognitive ability was controlled by blood HA level. Now we can present that some healthy food, that is named HBF, can recovered 100% Alzheimer’s cognitive impairment by the decreasing the homocysteic acid in a peripheral blood. We made the open-trial of HBF on the Alzheimer’s and lewy bodies dementia’s cognitive recovery. Two male lewy bodies dementia patients, 11 female Alzheimer’s patients were enrolled. All patients were at end stage. They ingested HBF supplement 1.5g at every meals for 1-2 months. Their MMSE scores were measured before and after their HBF ingestion. Their blood homocysteic acid levels were measured by ELISA method before and after their ingestions. Results were extremely amaging. 100% of all patients showed their cognitive recovery. Their blood homocysteic acid decreased their level by HBF. Now we have made a relative large open trial of AD patients. 91 patients were enrolled. Their cognitive recovery were measured by NM scale (New Clinical Scale for Rating of Mental States). All patients who took HBF showed the recovery of their behaviors. From this open-trial of HBF, many facts can be confirmed. (1) Alzheimer’s cognitive impairment can be recovered at even end stage. (2) Alzheimer’s disease is induced by homocysteic acid.