Abstract
Influenza A viruses pose an ongoing threat due to their role in seasonal epidemics and the potential for the emergence of novel viruses from the animal reservoir. 1 Kerstetter L.J. Buckley S. Bliss C.M. Coughlan L. Adenoviral vectors as vaccines for emerging avian influenza viruses. Front. Immunol. 2020; 11607333https://doi.org/10.3389/fimmu.2020.607333 Crossref PubMed Scopus (12) Google Scholar Extensive efforts are being made to develop vaccines that elicit protection against multiple influenza virus antigens, as well as universal vaccines that confer broad protection against antigenically distinct seasonal and/or pandemic viruses. In order to achieve long-lived and cross-protective immunity, it is considered that combining distinct vaccine platforms in heterologous prime:boost regimens may be required. 2 Coughlan L. Palese P. Overcoming barriers in the path to a universal influenza virus vaccine. Cell Host Microbe. 2018; 24: 18-24https://doi.org/10.1016/j.chom.2018.06.016 Abstract Full Text Full Text PDF PubMed Scopus (54) Google Scholar
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