Abstract
Aluminum and its potential contribution to Alzheimer's disease (AD).
Highlights
Alzheimer’s disease (AD) is perhaps the principal example of cognitive failure in humans, and currently over 5.5 million Americans suffer from this incapacitating and progressive disorder of thought, reasoning and memory
Our laboratory has been evaluating the potential contribution of environmentally bioavailable neurotoxic metals to the onset, development and progression of AD for about 30 years (Lukiw et al, 1987)
Abundant research indicates that aluminum is a reactive metal toward multiple aspects of human neurobiology and the altered genetics that are associated with the development and propagation of sporadic AD (Lukiw et al, 1989; Lukiw, 2010; Bhattacharjee et al, 2013; Bondy, 2013; Shaw and Tomljenovic, 2013; Walton, 2013)
Summary
Alzheimer’s disease (AD) is perhaps the principal example of cognitive failure in humans, and currently over 5.5 million Americans suffer from this incapacitating and progressive disorder of thought, reasoning and memory.
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