Abstract
Many neurological diseases, including autism, depression, dementia, anxiety disorder and Parkinson’s disease, are associated with abnormal sleep patterns, which are directly linked to pineal gland dysfunction. The pineal gland is highly susceptible to environmental toxicants. Two pervasive substances in modern industrialized nations are aluminum and glyphosate, the active ingredient in the herbicide, Roundup?. In this paper, we show how these two toxicants work synergistically to induce neurological damage. Glyphosate disrupts gut bacteria, leading to an overgrowth of Clostridium difficile. Its toxic product, p-cresol, is linked to autism in both human and mouse models. p-Cresol enhances uptake of aluminum via transferrin. Anemia, a result of both aluminum disruption of heme and impaired heme synthesis by glyphosate, leads to hypoxia, which induces increased pineal gland transferrin synthesis. Premature birth is associated with hypoxic stress and with substantial increased risk to the subsequent development of autism, linking hypoxia to autism. Glyphosate chelates aluminum, allowing ingested aluminum to bypass the gut barrier. This leads to anemia-induced hypoxia, promoting neurotoxicity and damaging the pineal gland. Both glyphosate and aluminum disrupt cytochrome P450 enzymes, which are involved in melatonin metabolism. Furthermore, melatonin is derived from tryptophan, whose synthesis in plants and microbes is blocked by glyphosate. We also demonstrate a plausible role for vitamin D3 dysbiosis in impaired gut function and impaired serotonin synthesis. This paper proposes that impaired sulfate supply to the brain mediates the damage induced by the synergistic action of aluminum and glyphosate on the pineal gland and related midbrain nuclei.
Highlights
Sleep disorders are associated with a large number of neurological diseases and conditions, including autism [1], attention deficit hyperactivity disorder (ADHD) [2]-[4], depression [5], Parkinson’s disease [6]-[8], schizophrenia [9]-[11], anxiety disorder [12], amyotrophic lateral sclerosis (ALS) [13], and Alzheimer’s disease [14]
We have developed the argument that a synergistic interaction between aluminum and glyphosate can lead to severe impairment of pineal gland function, and that this could explain the association of sleep disorder with a wide range of neurological diseases, and likely even help explain the related pathologies of those diseases
We have developed the argument that glyphosate, the active ingredient in the herbicide, Roundup, and aluminum, a pervasive toxic metal in our environment, operate synergistically to induce dysfunction in the pineal gland leading to the sleep disorder that is characteristic of multiple neurological diseases, including autism, ADHD, depression, Alzheimer’s disease, ALS, anxiety disorder and Parkinson’s disease
Summary
Sleep disorders are associated with a large number of neurological diseases and conditions, including autism [1], attention deficit hyperactivity disorder (ADHD) [2]-[4], depression [5], Parkinson’s disease [6]-[8], schizophrenia [9]-[11], anxiety disorder [12], amyotrophic lateral sclerosis (ALS) [13], and Alzheimer’s disease [14]. Nevison analyzed data spanning several decades to reach the conclusion that 75% 80% of the increase is real, and she hypothesized that this increase is due to environmental chemicals [19]. In her analysis of the temporal trends of a large number of different chemicals considered to be plausibly causal in autism, she identified only three with significant increases in exposure over time that aligned well with the increasing trend in autism: glyphosate, aluminum vaccine adjuvant and polybrominated diphenyl ethers (used as flame retardants) [19]
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