Abstract
AbstractWet granulation experiments on aluminium-; magnesium hydroxide; mannitol blends were carried out, in order to produce chewable antacid tablets.The influence of binder solvent, of type and concentration of polyvinylpyrrolidone as a binder and of granulating and drying equipment on the granule and tablet characteristics was investigated.Water as a binder solvent offered several advantages over the use of alcohol. The use of high molecular weight polyvinylpyrrolidone reduced the antacid capacity and caused some manufacturing problems.The granulating equipment (high shear granulator or planetary mixer) and the drying technique (oven or fluidized bed) had no major influence on the granule and tablet characteristics.
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