Abstract
Five new perylenequinone derivatives, altertoxins VIII–XII (1–5), as well as one known compound cladosporol I (6), were isolated from the fermentation broth of the marine-derived fungus Cladosporium sp. KFD33 from a blood cockle from Haikou Bay, China. Their structures were determined based on spectroscopic methods and ECD spectra analysis along with quantum ECD calculations. Compounds 1–6 exhibited quorum sensing inhibitory activities against Chromobacterium violaceum CV026 with MIC values of 30, 30, 20, 30, 20 and 30 μg/well, respectively.
Highlights
The unremitting discovery of antibiotics showed a promising prospect for the bacterial infections, and resulted in the serious resistance of antibiotics
The 13C NMR and HSQC spectra showed 20 carbon signals assigned to four methylenes, 14 aromatic carbons with five
HSQC spectra showed 20 carbon signals assigned to four methylenes, 14 aromatic carbons with five protonated, one oxygenated sp3 methine, and a conjugated ketone carbonyl
Summary
The unremitting discovery of antibiotics showed a promising prospect for the bacterial infections, and resulted in the serious resistance of antibiotics. QSIs can be used to disarm pathogens in the host and are not easy to cause bacterial resistance compared to conventional antibiotics [4,5]. The search for efficient QSIs is supposed to be an effective method to solve problems of bacterial infection and antibiotic resistance. Our previous research on new bioactive metabolites from the marine-derived fungi has led to the isolation and identification of many new QSIs, such as aculene E and penicitor B, aculene C, aculene D, aspergillumarins A–B [8], asperochrin D, asperochrin F, (3R,4R)-4,7-dihydroxymellein, asperochrin A, and asteltoxin [9]. The EtOAc extract of the fermentation broth of this fungus showed obvious QS inhibitory. The isolation, structure elucidation, and QS inhibitory. The isolation, structure elucidation, and QS inhibitory activity of activity of compounds.
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