Abstract
On our ongoing searching for bioactive natural products derived from entophytes, two polyketides possessing novel skeletons, alternatones A–B (1–2), were identified from the culture of Alternaria alternate L-10. Their structures were established by a combination of spectroscopic and single-crystal X-ray diffraction with Cu Ka radiation. Alternatone A (1) exhibited cytotoxic activity against human hepatoma carcinoma HepG-2 cell line. The putative biosynthetic pathways for compounds 1–2 were also proposed.
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