Abstract
Ingredients of cosmetic products are no longer allowed to be tested by animal experimentation (EU-Cosmetics Directive 76/768 EEC). For several toxicological endpoints this testing ban applies since March 11, 2009, while repeated dose toxicity tests and the test on skin sensitisation will follow on March 11, 2013. All currently available alternatives meeting the requirements of the first deadline are compiled in the following.
Highlights
A list of alternatives to the use of animals in safety testing, which covers the requirements of the 7th amendment of the EU Cosmetics Directive, which entered into force on March 11, 2009, is presented
Alternative methods to animal experiments are described in Annex IX of the EU Cosmetics Directive
This Annex should be updated as follows: Annex IX This Annex lists the alternative methods accepted worldwide as OECD guidelines, which are, available to meet the requirements of this Directive
Summary
Every new toxicological test method must pass through a defined procedure of validation and regulatory acceptance. This worldwide agreed procedure is modular, which allows a flexible application of only those modules that are necessary for a final implementation of a certain new method. Tab. 1: Steps towards a new test method according to a harmonised OECD validation concept (1996)
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