Abstract
Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins can regulate AS in a cell type-specific manner and determine the functions of cells. In addition to being involved in telomerase activity regulation, AS provides cells with different splice variants that may have alternative biological activities. The modulation of telomerase activity through the induction of hTERT AS is involved in the development of different cancer types and embryos, and the differentiation of stem cells. Regulatory T cells may suppress the proliferation of target human and murine T and B lymphocytes and NK cells in a contact-independent manner involving activation of TERT AS. This review focuses on the mechanism of regulation of hTERT pre-mRNA AS and the involvement of splice variants in physiological and pathological processes.
Highlights
The most frequent mechanism for telomere elongation among various cells is the functioning of telomerase, a ribonucleoprotein complex consisting of two key subunits: human telomerase RNA, which acts as a transcription template for newly synthetized telomeres, and human telomerase reverse transcriptase, whose enzymatic activity controls the grade of telomerase activity
The results suggested that a RNA secondary structures may sterically provide occlusion, exposure, or approximation minimum of nine 38-bp repeats is necessary for RNA:RNA pairing in human telomerase reverse transcriptase (hTERT) pre-mRNA to of cis-elements
The most obvious issues are how lncRNA is transcribed from the noncoding strand of the hTERT gene; why endonuclease G (EndoG) creates an EndoG-produced oligonucleotides (EGPOs) of this size as soon as other G-rich islands are present in lnc-RNA; why EGPO complements the junction site of exon 8 - intron 8 of hTERT pre-mRNA, and what other proteins are involved in this process
Summary
The AS mechanism is a tissue-specific process, and the formation of mature splice variants of a given pre-mRNA depends on the repertoire of splicing-regulatory proteins and on features of spliceosome regulation [17]. Splice variants mRNA may be translated to variants that have funcactivity are highly regulated at many levels, including promoter core region organization, tions that are frequently different from the full-length form, or in cases of altered capacity protein folding, post-translational and interaction partners [7]. Regulation for translation, such splicemodification, variants are degraded by nonsense-mediated decay [16]. Splice variants is in good agreement with the grade of telomerase activity in normal cells and inSplice cells from pathological
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
