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Abstract
Alternative splicing of α1 and β1 sGC genes is altered in aortic disease
Highlights
Soluble guanylyl cyclase plays an important role in cardiovascular homeostasis and its activity is crucial for maintaining vascular plasticity
Alternative splicing of a1 and b1 Soluble guanylyl cyclase (sGC) genes is altered in aortic disease
We have previously demonstrated that alternative splicing of sGC transcripts produces sGC splice forms with altered enzymatic and regulatory properties
Summary
Soluble guanylyl cyclase (sGC) plays an important role in cardiovascular homeostasis and its activity is crucial for maintaining vascular plasticity. Alternative splicing of a1 and b1 sGC genes is altered in aortic disease Diminished sGC expression and activity is associated with the development of endothelial dysfunction and increase in vascular stiffness. Splicing of sGC genes in human aortic tissue was never investigated.
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