Abstract
Alternative splicing of pre-mRNA is a key mechanism for increasing the complexity of proteins in humans, causing a diversity of expression of transcriptomes and proteomes in a tissue-specific manner. Alternative splicing is regulated by a variety of splicing factors. However, the changes and errors of splicing regulation caused by splicing factors are strongly related to many diseases, something which represents one of this study’s main interests. Further understanding of alternative splicing regulation mediated by cellular factors is also a prospective choice to develop specific drugs for targeting the dynamic RNA splicing process. In this review, we firstly concluded the basic principle of alternative splicing. Afterwards, we showed how splicing isoforms affect physiological activities through specific disease examples. Finally, the available treatment methods relative to adjusting splicing activities have been summarized.
Highlights
Another approach approved by the FDA is antisense oligonucleotide (ASO), which is based on technology used to modify RNA splicing with complementary sequences
This review describes thatthat alternative splicing is a complex physiological process inteThis review describes alternative splicing is a complex physiological process grating many regulatory factors
Correct alternative splicing depends on the approcis-acting elements, every accurate step of step spliceosome assembly, specific specific
Summary
Alternative splicing is an essential process in post-transcriptional mRNA processing, and produces various mature mRNAs with different structures and functions. In this process, exons are taken together in different combinations and introns are removed. Recent data indicate that each transcript of protein-coding genes contain 11 exons and produce 5.4 mRNAs on average [1]. TTN which encodes muscle protein titin and contains 364 coding-exons and 4039 different splicing events which have been identified by RNA-sequencing [3]. Most genes generate at least two transcript variants. The alternative spliced mRNAs are further translated into many protein variants which differ in function and structure.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
