Abstract
Alternative methodology for the study of infrared-A radiation effects on human skin
Highlights
Infrared radiation (IR-A) causes structural changes in the skin, similar to those caused by prolonged exposure to ultraviolet radiation
Graph 1 depicts the effects of infrared radiation type A (IR-A) radiation on the production of MMP-1, tissue inhibitors of metalloproteinases (TIMPs)-1 and GADD45a in cultured human fibroblasts
In Graph 2, it is possible to observe the results obtained after the exposure of human skin fragments to IR-A irradiation, which promoted a statistically significant increase (65.5%) in the production of MMP-1 in addition to a significant reduction in the synthesis of GADD45a (41.6%)
Summary
Infrared radiation (IR-A) causes structural changes in the skin, similar to those caused by prolonged exposure to ultraviolet radiation. Objective: The objective of this study was to correlate IR-A radiation effects in biopsies and in ex vivo skin fragments and in human fibroblasts culture by quantifying MMP-1, TIMP-1 and GADD45a mediators. Infrared radiation-A reaches deeper layers of the skin, with 35% of the radiation being dispersed in the epidermis, 48% in the dermis and 17% in the subcutaneous tissue.[2, 4] not yet completely understood, the mechanism by which IR-A radiation causes harmful effects involves disturbances in the transportation of mitochondrial electrons, leading to a decrease in energy production and an increase in the formation of reactive oxygen species. In vitro trials predict possible toxic effects and determine probable biological mechanisms of action responsible for the clinical benefit of the cosmetic product, complementing the in vivo results. Clinical results offer an undeniable contribution to the assessment of safety and efficacy of cosmetic products, they do not provide data regarding the mechanisms of action such as those obtained by in vitro techniques
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