Abstract
High-resolution continuum source graphite furnace atomic absorption spectrometry (HR-CS GF AAS) was used to develop an analytical method for chromium determination in pharmaceutical drugs through direct analysis of solid samples. The limit of detection and quantification were, respectively, 2.9μgkg−1 and 9.7μgkg−1 and the characteristic mass was 2.0pg. Eighteen pharmaceutical drugs and three excipients were analyzed. The encapsulated samples were opened and only its powder content was analyzed; the tablet samples were grinded before the analysis. The results obtained from the direct analysis of the solid samples were in agreement with those found after total digestion of samples using a closed-vessel microwave oven device, with a confidence level of 95%. The Cr concentration obtained for the different capsules and tablets investigated varied between 0.05 and 1.92mgkg−1. The proposed method is fast, reliable and simple for routine pharmaceutical analysis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
